Naloxone hydrochloride

Name: Naloxone hydrochloride
Brand: Tocris Bioscience
SKU: 0599

Tocris Bioscience, part of Bio-Techne | Catalog # 0599

Citations (102)

COA / SDS

Non-selective opioid antagonist

Key Product Details

Description:	Non-selective opioid antagonist
Chemical Name:	(5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	363.84

View Full Technical Details for Naloxone hydrochloride

Technical Data
Citations

Biological Activity for Naloxone hydrochloride

Naloxone hydrochloride is an opioid antagonist.

Technical Data for Naloxone hydrochloride

M. Wt	363.84
Formula	C₁₉H₂₁NO₄.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	357-08-4
PubChem ID	5464092
InChi Key	RGPDIGOSVORSAK-STHHAXOLSA-N
Smiles	Cl.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC=C)CC[C@@]14[C@@]5(O)CCC2=O)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Naloxone hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	36.38	100

Preparing Stock Solutions for Naloxone hydrochloride

The following data is based on the product molecular weight 363.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.74 mL	27.48 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
10 mM	0.27 mL	1.37 mL	2.75 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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Reconstitution Calculator

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References for Naloxone hydrochloride

References are publications that support the biological activity of the product.

Spivak Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity. Mol.Pharmacol. 1997 PMID: 9415708
Olson Endogenous opiates: 1995. Peptides
Pinelli and Trivulzio Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with mor. and injected with naloxone, in the absence or presence of the antiabstinence agent clon. J.Pharmacol.Toxicol.Methods 1997 PMID: 9523765