Narciclasine

Name: Narciclasine
Brand: Tocris Bioscience
SKU: 3715

Tocris Bioscience, part of Bio-Techne | Catalog # 3715

Citations (7)

COA / SDS

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

Key Product Details

Chemical Name:	(2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
Purity:	≥98%
Molecular Weight:	307.26 kDa

View Full Technical Details for Narciclasine

Technical Data
Citations

Biological Activity for Narciclasine

Narciclasine is an exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC₅₀ = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.

Technical Data for Narciclasine

M. Wt	307.26 kDa
Formula	C₁₄H₁₃NO₇
Storage	Store at -20°C
Purity	≥98%
CAS Number	29477-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Narciclasine

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Narciclasine

References are publications that support the biological activity of the product.

Dumont et al. The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia, 2007;9:766 PMID: 17898872
Ingrassia et al. Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents. J.Med.Chem., 2009;52:1100 PMID: 19199649
Lefranc et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol.Cancer Ther., 2009;8:1739 PMID: 19531573