Nateglinide

Name: Nateglinide
Brand: Tocris Bioscience
SKU: 4231

Tocris Bioscience, part of Bio-Techne | Catalog # 4231

Citations (3)

COA / SDS

Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels

Key Product Details

Description:	K_ir6 (K_ATP) blocker; displays high affinity for SUR1/K_ir6.2 channels
Alternative Names:	A-4166,Senaglinide
Chemical Name:	N-[[4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine
Molecular Weight:	317.42

View Full Technical Details for Nateglinide

Technical Data
Citations

Biological Activity for Nateglinide

Nateglinide is a k_ir6 (K_ATP) blocker. Exhibits in vitro tissue selectivity for pancreatic β-cell-type K_ir6 channels over cardiovascular K_ir6 channels; displays high affinity for SUR1/K_ir6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β-cells by increasing cytosolic Ca²⁺ concentration. Also agonist at the orphan receptor MRGPRX4.

Compound Libraries for Nateglinide

Nateglinide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Nateglinide

M. Wt	317.42
Formula	C₁₉H₂₇NO₃
Storage	Store at RT
CAS Number	105816-04-4
PubChem ID	5311309
InChi Key	OELFLUMRDSZNSF-OFLPRAFFSA-N
Smiles	O=[C@](N[C@@H](C(O)=O)CC2=CC=CC=C2)[C@H]1CC[C@H]([C@H](C)C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nateglinide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.74	100

Preparing Stock Solutions for Nateglinide

The following data is based on the product molecular weight 317.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.75 mL	31.50 mL
5 mM	0.63 mL	3.15 mL	6.30 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for Nateglinide

References are publications that support the biological activity of the product.

Kroeze PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nat.Struct.Mol.Biol. 2015 PMID: 25895059
Chachin Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type K_ATP channels. J.Pharmacol.Exp.Ther. 2003 PMID: 12604678
Fujitani The ability of a new hypoglycemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca²⁺ in pancreatic beta-cells under metabolic inhibition. Br.J.Pharmacol. 1997 PMID: 9105692
Hu Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and β-cell K_ATP channels. J.Pharmacol.Exp.Ther. 1999 PMID: 10565863
Shinkai N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents. J.Med.Chem. 1989 PMID: 2738878