Necrosulfonamide

Name: Necrosulfonamide
Brand: Tocris Bioscience
SKU: 5025

Tocris Bioscience, part of Bio-Techne | Catalog # 5025

(1)

Citations (48)

COA / SDS

Necroptosis inhibitor; also inhibits pyroptosis

Key Product Details

Chemical Name:	(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
Purity:	≥98%

View Full Technical Details for Necrosulfonamide

Technical Data
Citations / Reviews (1)

Biological Activity for Necrosulfonamide

Necrosulfonamide is a necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

Technical Data for Necrosulfonamide

Formula	C₁₈H₁₅N₅O₆S₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	1360614-48-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Necrosulfonamide

Solubility

Soluble Soluble to 20 mM in DMSO

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References for Necrosulfonamide

References are publications that support the biological activity of the product.

Zhou et al. New components of the necroptotic pathway. Protein Cell, 2012;3:811 PMID: 23073834
Sun et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell, 2012;148:213 PMID: 22265413
Kreuzaler et al. Killing a cancer: what are the alternatives? Nat.Rev.Cancer., 2012;12:411 PMID: 22576162
Pandeya et al. Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm, 2019;10:660 PMID: 31191857

Necrosulfonamide

Tocris Bioscience, part of Bio-Techne | Catalog # 5025

Key Product Details

Biological Activity for Necrosulfonamide

Technical Data for Necrosulfonamide

Solubility for Necrosulfonamide

Dilution Calculator

Reconstitution Calculator

References for Necrosulfonamide

Product Documents for Necrosulfonamide

COA

Certificate of Analysis

SDS

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