Nepicastat hydrochloride

Name: Nepicastat hydrochloride
Brand: Tocris Bioscience
SKU: 5037

Tocris Bioscience, part of Bio-Techne | Catalog # 5037

Citations (1)

COA / SDS

Potent and selective dopamine β-hydroxylase (DBH) inhibitor; orally bioavailable

Key Product Details

Chemical Name:	5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Nepicastat hydrochloride

Nepicastat hydrochloride is a potent and selective dopamine β-hydroxylase (DBH) inhibitor (IC₅₀ = 9 nM). Selective for DBH over 12 other enzymes. Decreases noradrenaline and increases dopamine levels in tissues and plasma in hypertensive rats. Prevents progressive left ventricular dysfunction in an in vivo heart failure model. Also potentiates the stimulus effects of cocaine without producing cocaine-like effects in rats. Orally bioavailable.

Technical Data for Nepicastat hydrochloride

Formula	C₁₄H₁₅F₂N₃S.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	170151-24-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nepicastat hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Nepicastat hydrochloride

References are publications that support the biological activity of the product.

Stanley et al. Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of DA-beta-hydroxylase. Br.J.Pharmacol., 1997;121:1803 PMID: 9283721
Manvich et al. DA β-hydroxylase inhibitors enhance the discriminative stimulus effects of cocaine in rats. J.Pharmacol.Exp.Ther., 2013;347:564 PMID: 24068832
Sabbah et al. Effects of DA β-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Circulation, 2000;102:1990 PMID: 11034950

Nepicastat hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5037

Key Product Details

Biological Activity for Nepicastat hydrochloride

Technical Data for Nepicastat hydrochloride

Solubility for Nepicastat hydrochloride

Dilution Calculator

Reconstitution Calculator

References for Nepicastat hydrochloride

Product Documents for Nepicastat hydrochloride

COA

Certificate of Analysis

SDS

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