NFAT Inhibitor

Name: NFAT Inhibitor
Brand: Tocris Bioscience
SKU: 3930

Tocris Bioscience, part of Bio-Techne | Catalog # 3930

Citations (10)

COA / SDS

Inhibitor of calcineurin-mediated NFAT activation

Key Product Details

Purity:	≥95%
Molecular Weight:	1683.94 kDa

View Full Technical Details for NFAT Inhibitor

Technical Data
Citations

Biological Activity for NFAT Inhibitor

NFAT Inhibitor is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Technical Data for NFAT Inhibitor

M. Wt	1683.94 kDa
Formula	C₇₅H₁₁₈N₂₀O₂₂S
Storage	Store at -20°C
Purity	≥95%
CAS Number	249537-73-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NFAT Inhibitor

Solubility

Soluble Soluble to 2 mg/ml in water

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References for NFAT Inhibitor

References are publications that support the biological activity of the product.

T Hadi, L Boytard, M Silvestro, D Alebrahim, S Jacob, J Feinstein, K Barone, W Spiro, S Hutchison, R Simon, D Rateri, F Pinet, D Fenyo, M Adelman, KJ Moore, HK Eltzschig, A Daugherty, B Ramkhelawo Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells Nat Commun, 2018;9(1):5022. 2018 PMID: 30479344
Aramburu et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science, 1999;285:2129 PMID: 10497131
Nagamoto-Combs and Combs Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells). J.Neurosci., 2010;30:9641 PMID: 20631193
Roehrl et al. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.USA, 2004;101:7554