NFPS

Name: NFPS
Brand: Tocris Bioscience
SKU: 2789

Tocris Bioscience, part of Bio-Techne | Catalog # 2789

Citations (15)

COA / SDS

Selective non-transportable GlyT1 inhibitor

Key Product Details

Description:	Selective non-transportable GlyT1 inhibitor
Alternative Names:	(±)-NFPS
Chemical Name:	N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine
Purity:	≥98% (HPLC)
Molecular Weight:	393.45

View Full Technical Details for NFPS

Technical Data
Citations

Biological Activity for NFPS

NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC₅₀ values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.

R-enantiomer also available.

Technical Data for NFPS

M. Wt	393.45
Formula	C₂₄H₂₄FNO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	405225-21-0
PubChem ID	5311283
InChi Key	FDORQEIHOKEJNX-UHFFFAOYSA-N
Smiles	FC1=CC=C(C(OC2=CC=C(C3=CC=CC=C3)C=C2)CCN(C)CC(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NFPS

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.93	10
	ethanol	1.97	5 with gentle warming

Preparing Stock Solutions for NFPS

The following data is based on the product molecular weight 393.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.42 mL	127.08 mL	254.16 mL
0.5 mM	5.08 mL	25.42 mL	50.83 mL
1 mM	2.54 mL	12.71 mL	25.42 mL
5 mM	0.51 mL	2.54 mL	5.08 mL

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Reconstitution Calculator

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References for NFPS

References are publications that support the biological activity of the product.

Harsing Jr. The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacol.Biochem.Behav.
Mallorga Pharmacology and expression analysis of glycine transporter GlyT1 with [³H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology 2003 PMID: 12941372
Bergeron Modulation of N-MthD.-aspartate receptor function by glycine transport. Proc.Natl.Acad.Sci.USA