NGI 1

Name: NGI 1
Brand: Tocris Bioscience
SKU: 6652

Tocris Bioscience, part of Bio-Techne | Catalog # 6652

Citations (3)

COA / SDS

Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral

Key Product Details

Chemical Name:	5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for NGI 1

NGI 1 is an oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC₅₀ values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.

Technical Data for NGI 1

Formula	C₁₇H₂₂N₄O₃S₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	790702-57-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NGI 1

Solubility

Soluble Soluble to 100 mM in DMSO

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References for NGI 1

References are publications that support the biological activity of the product.

Puschnik et al. A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity. Cell Rep., 2017;21:3032 PMID: 29241533
Lopez-Sambrooks et al. Oligosaccharyltransferase inhibition overcomes therapeutic resistance to EGFR tyrosine kinase inhibitors. Cancer Res., 2018;78:5094 PMID: 30026325
Lopez-Sambrooks et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat.Chem.Biol., 2016;12:1023 PMID: 27694802

NGI 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6652

Key Product Details

Biological Activity for NGI 1

Technical Data for NGI 1

Solubility for NGI 1

Dilution Calculator

Reconstitution Calculator

References for NGI 1

Product Documents for NGI 1

COA

Certificate of Analysis

SDS

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