Niclosamide

Name: Niclosamide
Brand: Tocris Bioscience
SKU: 4079

Tocris Bioscience, part of Bio-Techne | Catalog # 4079

Citations (9)

COA / SDS

STAT3 inhibitor; also inhibits mTORC1 signaling

Key Product Details

Chemical Name:	5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Purity:	≥99%
Molecular Weight:	325.99 kDa

View Full Technical Details for Niclosamide

Technical Data
Citations

Biological Activity for Niclosamide

Niclosamide is an inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Niclosamide displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. It inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. It also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. In addition, niclosamide inhibits SARS-CoV-2 replication in vitro (IC₅₀ = 0.34 μM in Vero E6 plaque assay) through suppression of TMEM16F activity.

Technical Data for Niclosamide

M. Wt	325.99 kDa
Formula	C₁₃H₈Cl₂N₂O₄
Storage	Store at +4°C
Purity	≥99%
CAS Number	50-65-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Niclosamide

Solubility

Soluble Soluble to 25 mM in ethanol and to 10 mM in DMSO

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References for Niclosamide

References are publications that support the biological activity of the product.

SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch Cell Rep, 2020;31(1):107472. 2020 PMID: 32268102
Natarajan, Rajalaxm, Singal, Vinamrat, Benes, Richard, Gao, Junling, Chan, Hoi, Chen, Haijun, Yu, Yongjia, Zhou, Jia, Wu, Ping STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. PLoS ONE, 2014;9(6):e100405. 2014 PMID: 24945434
Balgi et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One, 2009;4:e7124 PMID: 19771169
Jin et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-κB pathway and generation of reactive oxygen species. Cancer Res., 2010;70:2516 PMID: 20215516