Nicotinamide Riboside

Name: Nicotinamide Riboside
Brand: Tocris Bioscience
SKU: 6018

Tocris Bioscience, part of Bio-Techne | Catalog # 6018

Citations (1)

COA / SDS

NAD+ precursor; substrate for nicotinamide riboside kinases

Key Product Details

Description:	NAD⁺ precursor; substrate for nicotinamide riboside kinases
Chemical Name:	3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	290.7

View Full Technical Details for Nicotinamide Riboside

Technical Data
Citations

Biological Activity for Nicotinamide Riboside

Nicotinamide Riboside is an NAD⁺ precursor. It is a substrate for nicotinamide riboside kinases (NRK1/2). Nicotinamide Riboside shows neuroprotective effects in a mouse model of type 2 diabetes and improves mitochondrial function in muscle stem cells in aged mice. The compound also corrects non-alchoholic fatty liver disease phenotype induced by NAD⁺ deficiency or high-fat diet in mice. Orally bioavailable.

Technical Data for Nicotinamide Riboside

M. Wt	290.7
Formula	C₁₁H₁₅ClN₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	23111-00-4
PubChem ID	90480033
InChi Key	YABIFCKURFRPPO-IVOJBTPCSA-N
Smiles	NC(C1=C[N+]([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=CC=C1)=O.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nicotinamide Riboside

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.07	100
	water	29.07	100

Preparing Stock Solutions for Nicotinamide Riboside

The following data is based on the product molecular weight 290.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.44 mL	17.20 mL	34.40 mL
5 mM	0.69 mL	3.44 mL	6.88 mL
10 mM	0.34 mL	1.72 mL	3.44 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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References for Nicotinamide Riboside

References are publications that support the biological activity of the product.

Trammell Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice. Sci.Rep. 2016 PMID: 27230286
Zhou Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br.J.Pharmacol. 2016 PMID: 27174364
Zhang NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 2016 PMID: 27127236