NITD 008

Name: NITD 008
Brand: Tocris Bioscience
SKU: 6045

Tocris Bioscience, part of Bio-Techne | Catalog # 6045

Citations (5)

COA / SDS

Antiflaviviral; active against Zika, Dengue and Hepatitis C viruses

Key Product Details

Description:	Antiflaviviral; active against Zika, Dengue and Hepatitis C viruses
Chemical Name:	7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:	≥97% (HPLC)
Molecular Weight:	290.27

View Full Technical Details for NITD 008

Technical Data
Citations

Biological Activity for NITD 008

NITD 008 is a selective flavivirus inhibitor. Adenosine analog. Inhibits dengue virus (EC₅₀ = 0.64 μM), hepatitis C virus and cellular entry of Zika virus. Reduces increases of cytokines and NS1 and prevents death in dengue-infected mice. Active in vivo. Orally bioavailable.

Technical Data for NITD 008

M. Wt	290.27
Formula	C₁₃H₁₄N₄O₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1044589-82-3
PubChem ID	44633776
InChi Key	NKRAIOQPSBRMOV-NRMKKVEVSA-N
Smiles	NC1=C2C=CN(C2=NC=N1)[C@@H]3O[C@@H]([C@H]([C@@]3(C#C)O)O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NITD 008

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.81	20

Preparing Stock Solutions for NITD 008

The following data is based on the product molecular weight 290.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	17.23 mL	86.13 mL	172.25 mL
1 mM	3.45 mL	17.23 mL	34.45 mL
2 mM	1.72 mL	8.61 mL	17.23 mL
10 mM	0.34 mL	1.72 mL	3.45 mL

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References for NITD 008

References are publications that support the biological activity of the product.

Barrows A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell.Host.Microbe. 2016 PMID: 27476412
Yin An adenosine nucleoside inhibitor of dengue virus. Proc.Natl.Acad.Sci.USA. 2009 PMID: 19918064