NNC 711

Name: NNC 711
Brand: Tocris Bioscience
SKU: 1779

Tocris Bioscience, part of Bio-Techne | Catalog # 1779

Citations (34)

COA / SDS

Selective GAT-1 inhibitor

Key Product Details

Description:	Selective GAT-1 inhibitor
Chemical Name:	1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	386.88

View Full Technical Details for NNC 711

Technical Data
Citations

Biological Activity for NNC 711

NNC 711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC₅₀ values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo. Also exhibits cognition-enhancing activity.

Compound Libraries for NNC 711

NNC 711 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NNC 711

M. Wt	386.88
Formula	C₂₁H₂₂N₂O₃.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	145645-62-1
PubChem ID	123738
InChi Key	YZYRTEYMUTWJPL-UHFFFAOYSA-N
Smiles	O=C(C1=CCCN(CCO/N=C(C3=CC=CC=C3)/C2=CC=CC=C2)C1)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NNC 711

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.87	10
	DMSO	38.69	100

Preparing Stock Solutions for NNC 711

The following data is based on the product molecular weight 386.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.92 mL	25.85 mL
5 mM	0.52 mL	2.58 mL	5.17 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for NNC 711

References are publications that support the biological activity of the product.

Suzdak NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur.J.Pharmacol. 1992 PMID: 1468507
O'Connell Anti-ischemic and cognition-enhancing properties of NNC-711, a γ-aminobutyric acid reuptake inhibitor. Eur.J.Pharmacol. 2001 PMID: 11470258
Borden Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 1994 PMID: 7851497