NNMTi

Name: NNMTi
Brand: Tocris Bioscience
SKU: 6900

Tocris Bioscience, part of Bio-Techne | Catalog # 6900

Citations (2)

COA / SDS

Nicotinamide N-methyltransferase (NNMT) inhibitor; promotes myoblast differentiation

Key Product Details

Description:	Nicotinamide N-methyltransferase (NNMT) inhibitor; promotes myoblast differentiation
Chemical Name:	5-Amino-1-methylquinolinium iodide
Purity:	≥97% (HPLC)
Molecular Weight:	286.11

View Full Technical Details for NNMTi

Technical Data
Citations

Biological Activity for NNMTi

NNMTi is a nicotinamide N-methyltransferase (NNMT) inhibitor (IC₅₀ = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.

Technical Data for NNMTi

M. Wt	286.11
Formula	C₁₀H₁₁IN₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	42464-96-0
PubChem ID	66522933
InChi Key	JPEZFBFIRRAFNR-UHFFFAOYSA-N
Smiles	[I-].C[N+]1=CC=CC2=C(N)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NNMTi

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.61	100

Preparing Stock Solutions for NNMTi

The following data is based on the product molecular weight 286.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.50 mL	17.48 mL	34.95 mL
5 mM	0.70 mL	3.50 mL	6.99 mL
10 mM	0.35 mL	1.75 mL	3.50 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for NNMTi

References are publications that support the biological activity of the product.

Neelakantan Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 2017 PMID: 28548833
Neelakantan Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 2019 PMID: 30753815