Nogo-66 (1-40)

Name: Nogo-66 (1-40)
Brand: Tocris Bioscience
SKU: 1984

Tocris Bioscience, part of Bio-Techne | Catalog # 1984

Citations (17)

COA / SDS

Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration

Key Product Details

Purity:	≥95%
Molecular Weight:	4625.16 kDa

View Full Technical Details for Nogo-66 (1-40)

Technical Data
Citations

Biological Activity for Nogo-66 (1-40)

Nogo-66 (1-40) is a peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo.

Technical Data for Nogo-66 (1-40)

M. Wt	4625.16 kDa
Formula	C₂₀₆H₃₂₄N₅₆O₆₅
Storage	Store at -20°C
Purity	≥95%
CAS Number	475221-20-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nogo-66 (1-40)

Solubility

Soluble Soluble to 1 mg/ml in water

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References for Nogo-66 (1-40)

References are publications that support the biological activity of the product.

Kempf A, Tews B, Arzt M, Weinmann O, Obermair F, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab M The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS Biol, 2014;12(1):e1001763. 2014 PMID: 24453941
GrandPre et al. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature, 2002;417:547 PMID: 12037567
Liu et al. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science, 2002;297:1190 PMID: 12089450
Li and Strittmatter Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J.Neurosci., 2003;23:4219 PMID: 12764110