Nomifensine

Name: Nomifensine
Brand: Tocris Bioscience
SKU: 1992

Tocris Bioscience, part of Bio-Techne | Catalog # 1992

Citations (125)

COA / SDS

Potent noradrenalin and dopamine uptake inhibitor. Antidepressant

Key Product Details

Description:	Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
Chemical Name:	1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate
Purity:	≥98% (HPLC)
Molecular Weight:	354.4

View Full Technical Details for Nomifensine

Technical Data
Citations

Biological Activity for Nomifensine

Nomifensine is a potent inhibitor of noradrenaline and dopamine uptake (K_i values are 4.7, 26 and 4000 nM for inhibition of noradrenaline, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.

Technical Data for Nomifensine

M. Wt	354.4
Formula	C₁₆H₁₈N₂.C₄H₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	32795-47-4
PubChem ID	5358907
InChi Key	GEOCVSMCLVIOEV-BTJKTKAUSA-N
Smiles	NC1=CC=CC2=C1C[N+]([H])(C)CC2C3=CC=CC=C3.O=C(O)\C=C/C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nomifensine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.44	100

Preparing Stock Solutions for Nomifensine

The following data is based on the product molecular weight 354.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.11 mL	28.22 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for Nomifensine

References are publications that support the biological activity of the product.

Nakachi Effects of various DA uptake inhibitors on striatal extracellular DA levels and behaviours in rats. Eur.J.Pharmacol. 1995 PMID: 7589207
Katz Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J.Psychopharmacol. 2010 PMID: 19939862
Tuomisto Nomifensine and its derivatives as possible tools for studying amine uptake. Eur.J.Pharmacol. 1977 PMID: 844493