Nor NOHA monoacetate

Name: Nor NOHA monoacetate
Brand: Tocris Bioscience
SKU: 6370

Tocris Bioscience, part of Bio-Techne | Catalog # 6370

Citations (2)

COA / SDS

Arginase inhibitor

Key Product Details

Description:	Arginase inhibitor
Chemical Name:	(2S)-2-Amino-4-[[(hydroxyamino)iminomethyl]amino]butanoic acid monoacetate
Molecular Weight:	236.23

View Full Technical Details for Nor NOHA monoacetate

Technical Data
Citations

Biological Activity for Nor NOHA monoacetate

Nor NOHA monoacetate is a reversible, competitive arginase inhibitor (IC₅₀ = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.

Technical Data for Nor NOHA monoacetate

M. Wt	236.23
Formula	C₅H₁₂N₄O₃.C₂H₄O₂
Storage	Store at -20°C
CAS Number	2250019-93-1
PubChem ID	131648256
InChi Key	RYUGHGOGNIYFKU-DFWYDOINSA-N
Smiles	N[C@@H](CCNC(NO)=N)C(O)=O.O=C(O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nor NOHA monoacetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	23.62	100

Preparing Stock Solutions for Nor NOHA monoacetate

The following data is based on the product molecular weight 236.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.17 mL	42.33 mL
5 mM	0.85 mL	4.23 mL	8.47 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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References for Nor NOHA monoacetate

References are publications that support the biological activity of the product.

Rodriguez Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 2004 PMID: 15313928
Colleluori and Ash Classical and slow-binding inhibitors of human type II arginase. Biochemistry 2001 PMID: 11478904
Huynh The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br.J.Pharmacol. 2009 PMID: 19133993
Custot The new α-amino acid N^ω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster. J.Am.Chem.Soc.