NPE-caged-proton

Name: NPE-caged-proton
Brand: Tocris Bioscience
SKU: 3512
Rating: 1 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3512

(1)

Citations (3)

COA / SDS

Caged proton

Key Product Details

Description:	Caged proton
Alternative Names:	NPE-caged-sulfate
Chemical Name:	1-(2-Nitrophenyl)ethyl sulfate sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	269.21

View Full Technical Details for NPE-caged-proton

Technical Data
Citations / Reviews (1)

Biological Activity for NPE-caged-proton

NPE-caged-proton is a 1-(2-nitrophenyl)ethyl caged proton that releases a proton and a sulfate ion upon photolysis at 350 - 355 nm. Generates rapid acidifications (pH jumps) down to pH 2.

Technical Data for NPE-caged-proton

M. Wt	269.21
Formula	C₈H₈NNaO₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1186195-63-0
PubChem ID	57369362
InChi Key	LCCXAXUWDTVOHF-UHFFFAOYSA-M
Smiles	[O-][N+](C1=C(C(C)OS([O-])(=O)=O)C=CC=C1)=O.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NPE-caged-proton

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.92	100
	DMSO	26.92	100

Preparing Stock Solutions for NPE-caged-proton

The following data is based on the product molecular weight 269.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.57 mL	37.15 mL
5 mM	0.74 mL	3.71 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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Reconstitution Calculator

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References for NPE-caged-proton

References are publications that support the biological activity of the product.

Abbruzzetti Kinetics of proton release after flash photolysis of 1-(2-Nitrophenyl)ethyl sulfate (caged sulfate) in aqueous solution. J.Am.Chem.Soc. 2005 PMID: 15998092
Peralvarez-Marin Time-resolved infrared spectroscopy of pH-induced aggregation of the Alzheimer Aβ_1-28 peptide. J.Mol.Biol. 2008 PMID: 18462754
Barth and Corrie Characterization of a new caged proton capable of inducing large pH jumps. Biophys.J. 2002 PMID: 12414718