NPS 2390

Name: NPS 2390
Brand: Tocris Bioscience
SKU: 4134
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4134

(1)

Citations (10)

COA / SDS

Group I mGlu antagonist

Key Product Details

Description:	Group I mGlu antagonist
Chemical Name:	N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	307.39

View Full Technical Details for NPS 2390

Technical Data
Citations / Reviews (1)

Biological Activity for NPS 2390

NPS 2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu₁ and mGlu₅ receptors. Thought to act on a site separate from the glutamate binding pocket.

Compound Libraries for NPS 2390

NPS 2390 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NPS 2390

M. Wt	307.39
Formula	C₁₉H₂₁N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	226878-01-9
PubChem ID	7067728
InChi Key	ZKFVOZCCAXQXBU-UHFFFAOYSA-N
Smiles	O=C(C4=NC(C=CC=C5)=C5N=C4)NC1(CC3C2)CC(C3)CC2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NPS 2390

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	15.37	50
	ethanol	15.37	50

Preparing Stock Solutions for NPS 2390

The following data is based on the product molecular weight 307.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.51 mL	32.53 mL	65.06 mL
2.5 mM	1.30 mL	6.51 mL	13.01 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
25 mM	0.13 mL	0.65 mL	1.30 mL

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Reconstitution Calculator

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References for NPS 2390

References are publications that support the biological activity of the product.

Mabire Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. J.Med.Chem. 2005 PMID: 15771457
van Wagenen Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist. Abstr.Soc.Neurosci.
Lavreysen [³H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol.Pharmacol. 2003 PMID: 12695537