NS 11021

Name: NS 11021
Brand: Tocris Bioscience
SKU: 4788
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4788

(2)

Citations (14)

COA / SDS

KCa1.1 (BK) channel activator

Key Product Details

Description:	K_Ca1.1 (BK) channel activator
Chemical Name:	N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Purity:	≥98% (HPLC)
Molecular Weight:	511.24

View Full Technical Details for NS 11021

Technical Data
Citations / Reviews (2)

Biological Activity for NS 11021

NS 11021 is an activator of large-conductance Ca²⁺-activated potassium channels (BK_Ca, K_Ca1.1). Exhibits no modulatory effect on a variety of K⁺ (K_V), Na⁺ and Ca²⁺ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BK_Ca in open and closed conformations; thought to bind the α subunit.

Compound Libraries for NS 11021

NS 11021 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 11021

M. Wt	511.24
Formula	C₁₆H₉BrF₆N₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	956014-19-0
PubChem ID	24825677
InChi Key	MDKAFDIKYQMOMF-UHFFFAOYSA-N
Smiles	BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 11021

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	51.12	100
	DMSO	51.12	100

Preparing Stock Solutions for NS 11021

The following data is based on the product molecular weight 511.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.96 mL	9.78 mL	19.56 mL
5 mM	0.39 mL	1.96 mL	3.91 mL
10 mM	0.20 mL	0.98 mL	1.96 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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Reconstitution Calculator

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References for NS 11021

References are publications that support the biological activity of the product.

Bentzen The small molecule NS11021 is a potent and specific activator of Ca²⁺-activated big-conductance K⁺ channels. Mol.Pharmacol. 2007 PMID: 17636045
Kun NS11021, a novel opener of large-conductance Ca²⁺-activated K⁺ channels, enhances erectile responses in rats. Br.J.Pharmacol. 2009 PMID: 19845682
Layne BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 2009 PMID: 19923353