NS 19504

Name: NS 19504
Brand: Tocris Bioscience
SKU: 5276

Tocris Bioscience, part of Bio-Techne | Catalog # 5276

(1)

Citations (4)

COA / SDS

KCa1.1 (BK) channel activator

Key Product Details

Chemical Name:	5-[(4-Bromophenyl)methyl]-2-thiazolamine
Purity:	≥99%

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Technical Data
Citations / Reviews (1)

Biological Activity for NS 19504

NS 19504 is a selective activator of large-conductance Ca²⁺-activated potassium channels (BK_Ca, K_Ca1.1) (EC₅₀ = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K⁺ concentration or at 65 other receptors tested, including L- and N- type Ca²⁺ channels, Na_v, K_ATP and hERG channels.

Technical Data for NS 19504

Formula	C₁₀H₉BrN₂S
Storage	Store at +4°C
Purity	≥99%
CAS Number	327062-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 19504

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for NS 19504

References are publications that support the biological activity of the product.

Nausch et al. NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther., 2014;350:520 PMID: 24951278

NS 19504

Tocris Bioscience, part of Bio-Techne | Catalog # 5276

Key Product Details

Biological Activity for NS 19504

Technical Data for NS 19504

Solubility for NS 19504

Dilution Calculator

Reconstitution Calculator

References for NS 19504

Product Documents for NS 19504

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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