NS 309

Name: NS 309
Brand: Tocris Bioscience
SKU: 3895

Tocris Bioscience, part of Bio-Techne | Catalog # 3895

(1)

Citations (52)

COA / SDS

Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels

Key Product Details

Chemical Name:	6,7-Dichloro-1H-indole-2,3-dione 3-oxime
Purity:	≥98%
Molecular Weight:	231.04 kDa

View Full Technical Details for NS 309

Technical Data
Citations / Reviews (1)

Biological Activity for NS 309

NS 309 is a positive modulator of small- and intermediate- conductance Ca²⁺-activated K⁺ channels (K_Ca2 and K_Ca3.1 channels); increases Ca²⁺ sensitivity. Displays no activity at BK channels.

Technical Data for NS 309

M. Wt	231.04 kDa
Formula	C₈H₄Cl₂N₂O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	18711-16-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 309

Solubility

Soluble Soluble to 100 mM in DMSO

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References for NS 309

References are publications that support the biological activity of the product.

Grgic et al. Endothelial Ca²⁺-activated K⁺ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery. Br.J.Pharmacol., 2009;157:509 PMID: 19302590
Strobaek et al. Activation of human IK and SK Ca²⁺-activated K⁺ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim.Biophys.Acta, 2004;1665:1 PMID: 15471565