NSC 23766

Name: NSC 23766
Brand: Tocris Bioscience
SKU: 2161

Tocris Bioscience, part of Bio-Techne | Catalog # 2161

(1)

Citations (298)

COA / SDS

Selective inhibitor of Rac1-GEF interaction; antioncogenic

Key Product Details

Chemical Name:	N⁶-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
Purity:	≥99%
Molecular Weight:	530.97 kDa

View Full Technical Details for NSC 23766

Technical Data
Citations / Reviews (1)

Biological Activity for NSC 23766

NSC 23766 is a selective inhibitor of Rac1-GEF interaction. NSC 23766 prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC₅₀ ~ 50 μM) without affecting Cdc42 or RhoA activation. The compound inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotypes in prostate cancer cells. NSC 23766 also inhibits mammary carcinoma cell invasion in vitro and inhibits mammary tumor progression and metastasis in a mouse model.

Technical Data for NSC 23766

M. Wt	530.97 kDa
Formula	C₂₄H₃₅N₇.3HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	1177865-17-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 23766

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for NSC 23766

References are publications that support the biological activity of the product.

Sakurai T, Woolls M, Jin S, Murakami M, Simons M Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS ONE, 2014;9(6):e90736. 2014 PMID: 24603875
Lee H, Cheerathodi M, Chaki S, Reyes S, Zheng Y, Lu Z, Paidassi H, DerMardirossian C, Lacy-Hulbert A, Rivera G, McCarty J Protein tyrosine phosphatase-PEST and beta8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol, 2015;35(8):1401-13. 2015 PMID: 25666508
Kageyama Y, Doi T, Matsushima-Nishiwaki R, Iida Y, Akamatsu S, Kondo A, Kuroyanagi G, Yamamoto N, Mizutani J, Otsuka T, Tokuda H, Iida H, Kozawa O, Ogura S Involvement of Rac in thromboxane A2induced human platelet activation: regulation of sCD40 ligand release and PDGFAB secretion. Mol Med Rep, 2014;10(1):107-12. 2014 PMID: 24737161
Ke K, Sul O, Kim W, Lee M, Ko M, Suh J, Kim H, Kim S, Park J, Choi H Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss. Am J Physiol Endocrinol Metab, 2013;304(7):E703-10. 2013 PMID: 23360825
Lin L, Jin Y, Mars W, Reeves W, Hu K Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-kappaB pathways. Am J Pathol, 2014;184(10):2757-67. 2014 PMID: 25131752
CH Wu, CR Silvers, EM Messing, YF Lee Bladder cancer extracellular vesicles drive tumorigenesis byï¿½inducing the unfolded protein response in endoplasmic reticulum of non-malignant cells J. Biol. Chem., 2018;0(0):. 2018 PMID: 30593508
Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen Y TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-rac pathway. J Immunol, 2012;189(6):2768-73. 2012 PMID: 22904303
Kenny H, Chiang C, White E, Schryver E, Habis M, Romero I, Ladanyi A, Penicka C, George J, Matlin K, Montag A, Wroblewski K, Yamada S, Mazar A, Bowtell D, Lengyel E Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J Clin Invest, 2014;124(10):4614-28. 2014 PMID: 25202979
V Aragon-San, SE Pohler, VJ Eswar, M Bierowski, EW Gomez, C Dong VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells Sci Rep, 2017;7(0):45835. 2017 PMID: 28393886
NJ Weng, P Talbot The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells Stem Cell Res, 2017;23(0):39-49. 2017 PMID: 28672157
Harrison, Susan M, Knifley, Teresa, Chen, Min, O'Connor, Kathleen LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells. BMC Cancer, 2013;13(0):501. 2013 PMID: 24160245