NSC 617145

Name: NSC 617145
Brand: Tocris Bioscience
SKU: 5340

Tocris Bioscience, part of Bio-Techne | Catalog # 5340

Citations (2)

COA / SDS

Werner syndrome helicase (WRN) inhibitor

Key Product Details

Description:	Werner syndrome helicase (WRN) inhibitor
Chemical Name:	1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
Purity:	≥98% (HPLC)
Molecular Weight:	400.04

View Full Technical Details for NSC 617145

Technical Data
Citations

Biological Activity for NSC 617145

NSC 617145 is a werner syndrome helicase (WRN) helicase inhibitor (IC₅₀ = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.

Technical Data for NSC 617145

M. Wt	400.04
Formula	C₁₃H₁₀Cl₄N₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	203115-63-3
PubChem ID	357621
InChi Key	PCOXPBOKDABARQ-UHFFFAOYSA-N
Smiles	CC(CN1C(C(Cl)=C(Cl)C1=O)=O)(C)CN2C(C(Cl)=C(Cl)C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 617145

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8	20

Preparing Stock Solutions for NSC 617145

The following data is based on the product molecular weight 400.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.50 mL	62.49 mL	124.99 mL
1 mM	2.50 mL	12.50 mL	25.00 mL
2 mM	1.25 mL	6.25 mL	12.50 mL
10 mM	0.25 mL	1.25 mL	2.50 mL

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References for NSC 617145

References are publications that support the biological activity of the product.

Aggarwal Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 2013 PMID: 24036544
Aggarwal Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 2013 PMID: 23867477