nTZDpa

Name: nTZDpa
Brand: Tocris Bioscience
SKU: 2150

Tocris Bioscience, part of Bio-Techne | Catalog # 2150

Citations (2)

COA / SDS

Potent, selective PPARγ partial agonist

Key Product Details

Chemical Name:	5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
Purity:	≥98%
Molecular Weight:	428.33 kDa

View Full Technical Details for nTZDpa

Technical Data
Citations

Biological Activity for nTZDpa

nTZDpa is a potent, selective non-thiazolidinedione PPARγ partial agonist (EC₅₀ = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC₅₀ ~ 285 nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo.

Technical Data for nTZDpa

M. Wt	428.33 kDa
Formula	C₂₂H₁₅Cl₂NO₂S
Storage	Store at +4°C
Purity	≥98%
CAS Number	118414-59-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for nTZDpa

Solubility

Soluble Soluble to 100 mM in DMSO

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References for nTZDpa

References are publications that support the biological activity of the product.

Berger et al. Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator. Mol.Endocrinol., 2003;17:662 PMID: 12554792