NU 7441

Name: NU 7441
Brand: Tocris Bioscience
SKU: 3712
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3712

(1)

Citations (183)

COA / SDS

Potent and selective DNA-PK inhibitor

Key Product Details

Description:	Potent and selective DNA-PK inhibitor
Alternative Names:	KU 57788
Chemical Name:	8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
Purity:	≥99% (HPLC)
Molecular Weight:	413.49

View Full Technical Details for NU 7441

Technical Data
Citations / Reviews (1)

Biological Activity for NU 7441

NU 7441 is a potent and selective DNA-PK inhibitor (IC₅₀ = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%.

Technical Data for NU 7441

M. Wt	413.49
Formula	C₂₅H₁₉NO₃S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	503468-95-9
PubChem ID	11327430
InChi Key	JAMULYFATHSZJM-UHFFFAOYSA-N
Smiles	O=C1C3=C(C(C4=CC=CC5=C4SC6=C5C=CC=C6)=CC=C3)OC(N2CCOCC2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NU 7441

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.07	5 with gentle warming

Preparing Stock Solutions for NU 7441

The following data is based on the product molecular weight 413.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	48.37 mL	241.84 mL	483.69 mL
0.25 mM	9.67 mL	48.37 mL	96.74 mL
0.5 mM	4.84 mL	24.18 mL	48.37 mL
2.5 mM	0.97 mL	4.84 mL	9.67 mL

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References for NU 7441

References are publications that support the biological activity of the product.

Robert Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 2015 PMID: 26307031
Willmore DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin.Cancer Res. 2008 PMID: 18559621
Leahy Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg.Med.Chem.Lett. 2004 PMID: 15546735
Zhao Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 2006 PMID: 16707462