NU 7441

Biological Activity for NU 7441

Technical Data for NU 7441

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NU 7441

References for NU 7441

References are publications that support the biological activity of the product.

• Henriksson S, Rassoolzadeh H, Hedstrom E, Coucoravas C, Julner A, Goldstein M, Imreh G, Zhivotovsky B, Kastan M, Helleday T, Farnebo M The scaffold protein WRAP53beta orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev, 2014;28(24):2726-38. 2014 PMID: 25512560
• EA Smith, B Gole, NA Willis, R Soria, LM Starnes, EF Krumpelbec, AG Jegga, AM Ali, H Guo, AR Meetei, PR Andreassen, F Kappes, LM Vinnedge, JA Daniel, R Scully, L Wiesmüller, SI Wells DEK is required for homologous recombination repair of DNA breaks Sci Rep, 2017;7(0):44662. 2017 PMID: 28317934
• Zhou, Yi, Paull, Tanya T DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J Biol Chem, 2013;288(52):37112-25. 2013 PMID: 24220101
• SM Harding, JL Benci, J Irianto, DE Discher, AJ Minn, RA Greenberg Mitotic progression following DNA damage enables pattern recognition within micronuclei Nature, 2017;0(0):. 2017 PMID: 28759889
• Firat E, Weyerbrock A, Gaedicke S, Grosu A, Niedermann G Chloroquine or Chloroquine-PI3K/Akt Pathway Inhibitor Combinations Strongly Promote gamma-Irradiation-Induced Cell Death in Primary Stem-Like Glioma Cells. PLoS ONE, 2012;7(10):e47357. 2012 PMID: 23091617
• Mishra, Amarjit, Brown, Alexandr, Yao, Xianglan, Yang, Shutong, Park, Sung-Jun, Liu, Chengyu, Dagur, Pradeep, McCoy, J Philip, Keeran, Karen J, Nugent, Gayle Z, Jeffries, Kenneth, Qu, Xuan, Yu, Zu-Xi, Levine, Stewart, Chung, Jay H Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. Nat Commun, 2015;6(0):6224. 2015 PMID: 25692509
• Deng X, Yan Z, Cheng F, Engelhardt J, Qiu J Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways. PLoS Pathog, 2016;12(1):e1005399. 2016 PMID: 26765330
• Robert et al. Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med., 2015;7:93 PMID: 26307031
• Zhao et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res., 2006;66:5354 PMID: 16707462
• Willmore et al. DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin.Cancer Res., 2008;14:3984 PMID: 18559621
• Leahy et al. Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg.Med.Chem.Lett., 2004;14:6083 PMID: 15546735