O8 OGG1 Inhibitor

Name: O8 OGG1 Inhibitor
Brand: Tocris Bioscience
SKU: 6236

Tocris Bioscience, part of Bio-Techne | Catalog # 6236

Citations (2)

COA / SDS

Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

Key Product Details

Description:	Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
Chemical Name:	3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	261.13

View Full Technical Details for O8 OGG1 Inhibitor

Technical Data
Citations

Biological Activity for O8 OGG1 Inhibitor

O8 OGG1 Inhibitor is a potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC₅₀ = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.

Compound Libraries for O8 OGG1 Inhibitor

O8 OGG1 Inhibitor is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for O8 OGG1 Inhibitor

M. Wt	261.13
Formula	C₉H₆Cl₂N₂OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	350997-39-6
PubChem ID	874733
InChi Key	HSSHUDKWJRJKPV-UHFFFAOYSA-N
Smiles	NNC(=O)C1=C(Cl)C2=C(Cl)C=CC=C2S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for O8 OGG1 Inhibitor

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.11	100

Preparing Stock Solutions for O8 OGG1 Inhibitor

The following data is based on the product molecular weight 261.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.83 mL	19.15 mL	38.30 mL
5 mM	0.77 mL	3.83 mL	7.66 mL
10 mM	0.38 mL	1.91 mL	3.83 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for O8 OGG1 Inhibitor

References are publications that support the biological activity of the product.

Donley Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1). ACS Chem.Biol. 2015 PMID: 26218629