Obatoclax mesylate

Name: Obatoclax mesylate
Brand: Tocris Bioscience
SKU: 6539

Tocris Bioscience, part of Bio-Techne | Catalog # 6539

COA / SDS

Inhibitor of Bcl-2 family members; antiapoptotic

Key Product Details

Description:	Inhibitor of Bcl-2 family members; antiapoptotic
Alternative Names:	GX15-070
Chemical Name:	2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	413.49

View Full Technical Details for Obatoclax mesylate

Technical Data
Citations

Biological Activity for Obatoclax mesylate

Obatoclax mesylate is an inhibitor of Bcl-2 family members (IC₅₀ values are 1.11 - 7 μM). Inhibits the interaction of a BH3 domain peptide with 6 members of the Bcl-2 family (Bcl-2, Bcl-XL, Mcl-1, Bcl-W, A1, and Bcl-B) in vitro. Has antiapoptotic and antitumor effects in several tumor bearing mouse models.

Compound Libraries for Obatoclax mesylate

Obatoclax mesylate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Obatoclax mesylate

M. Wt	413.49
Formula	C₂₀H₁₉N₃O.CH₃SO₃H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	803712-79-0
PubChem ID	16681698
InChi Key	ZVAGBRFUYHSUHA-LZOXOEDVSA-N
Smiles	CS(O)(=O)=O.COC1=CC(C2=CC3=CC=CC=C3N2)=N/C1=C/C4=C(C=C(N4)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Obatoclax mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.67	50

Preparing Stock Solutions for Obatoclax mesylate

The following data is based on the product molecular weight 413.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.84 mL	24.18 mL	48.37 mL
2.5 mM	0.97 mL	4.84 mL	9.67 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
25 mM	0.10 mL	0.48 mL	0.97 mL

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References for Obatoclax mesylate

References are publications that support the biological activity of the product.

Zhai Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ. 2006 PMID: 16645636
Nguyen Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 18040043