Obtustatin

Name: Obtustatin
Brand: Tocris Bioscience
SKU: 4664
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4664

(1)

Citations (9)

COA / SDS

Potent and selective α1β1 inhibitor

Key Product Details

Description:	Potent and selective α₁β₁ inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	4393.07

View Full Technical Details for Obtustatin

Technical Data
Citations / Reviews (1)

Biological Activity for Obtustatin

Obtustatin is a highly potent integrin α₁β₁ inhibitor (IC₅₀ = 0.8 nM for α₁β₁ binding to type IV collagen). Selective for α₁β₁ over α₂β₁, α_IIbβ₃, α_vβ₃, α₄β₁, α₅β₆, α₉β₁ and α₄β₇. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.

Technical Data for Obtustatin

M. Wt	4393.07
Formula	C₁₈₄H₂₈₄N₅₂O₅₇S₈
Single Letter Sequence	CTTGPCCRQCKLKPAGTTCWKTSLTSHYCTGKSCDCPLYPG (Modifications: Disulfide bridges: 1-10, 6-29, 7-34, 19-36)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	404882-00-4
PubChem ID	90488962
InChi Key	XXWNADNJWWLFFP-UHFFFAOYSA-N
Smiles	[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@@H]4NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]5CCCN5C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N3)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CNC3=C1C=CC=C3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC4=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Obtustatin

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Obtustatin

References are publications that support the biological activity of the product.

Marcinkiewicz Obtustatin: a potent and selective inhibitor of α1β1 integrin in vitro and angiogenesis in vivo. Cancer Res. 2003 PMID: 12727812
Brown Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth. Int.J.Cancer 2008 PMID: 18712720
Moreno-Murciano Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa. Protein Sci. 2003 PMID: 12538900