OD 36 hydrochloride

Name: OD 36 hydrochloride
Brand: Tocris Bioscience
SKU: 6598

Tocris Bioscience, part of Bio-Techne | Catalog # 6598

COA / SDS

Potent RIP2 kinase inhibitor

Discontinued Product

6598 has been discontinued. View all RIP Kinase Inhibitors products.

Key Product Details

Description:	Potent RIP2 kinase inhibitor
Chemical Name:	6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	367.23

View Full Technical Details for OD 36 hydrochloride

Technical Data
Citations

Biological Activity for OD 36 hydrochloride

OD 36 hydrochloride is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC₅₀ = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.

Compound Libraries for OD 36 hydrochloride

OD 36 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for OD 36 hydrochloride

M. Wt	367.23
Formula	C₁₆H₁₅ClN₄O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1638644-62-8
Smiles	ClC1=CC(C2=C3N=C(NCCOCCO4)C=CN3N=C2)=CC4=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for OD 36 hydrochloride

References are publications that support the biological activity of the product.

Sánchez-Duffhues Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells. JBMRPlus 2019 PMID: 31768489
Tigno-Aranjuez In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J.Biol.Chem. 2014 PMID: 25213858