Oleylethanolamide

Name: Oleylethanolamide
Brand: Tocris Bioscience
SKU: 1484

Tocris Bioscience, part of Bio-Techne | Catalog # 1484

Citations (7)

COA / SDS

Lipid mediator, anorexic actions; also GPR55 and PPARα agonist

Key Product Details

Chemical Name:	(9Z)-N-(2-Hydroxyethyl)-9-octadecenamide
Purity:	≥99%
Molecular Weight:	325.53 kDa

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Technical Data
Citations

Biological Activity for Oleylethanolamide

Oleylethanolamide is a lipid mediator and analog of anandamide (Cat. No. 1339) that is involved in peripheral regulation of feeding. Selective GPR55 agonist (EC₅₀ values are 0.44, >30 and >30 μM at GPR55, CB₁ and CB₂ respectively) and PPARα agonist (EC₅₀ = 120 nM). Induces satiety through activation of PPARα and is also a ceramidase inhibitor. Also endogenous agonist at the GPR119 receptor.

Technical Data for Oleylethanolamide

M. Wt	325.53 kDa
Formula	C₂₀H₃₉NO₂
Storage	Store at +4°C
Purity	≥99%
CAS Number	111-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Oleylethanolamide

References are publications that support the biological activity of the product.

Ryberg et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol., 2007;152:1092 PMID: 17876302
Coroneos et al. Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. J.Biol.Chem., 1995;270:23305 PMID: 7559485
Calignano et al. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur.J.Pharmacol., 2001;419:191 PMID: 11426841
Fu et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature, 2003;425:90 PMID: 12955147
de Fonseca et al. An anorexic lipid mediator regulated by feeding. Nature, 2001;414:209 PMID: 11700558

Oleylethanolamide

Tocris Bioscience, part of Bio-Techne | Catalog # 1484

Key Product Details

Biological Activity for Oleylethanolamide

Technical Data for Oleylethanolamide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Oleylethanolamide

Product Documents for Oleylethanolamide

COA

Certificate of Analysis

SDS

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