Oltipraz

Name: Oltipraz
Brand: Tocris Bioscience
SKU: 5294

Tocris Bioscience, part of Bio-Techne | Catalog # 5294

Citations (2)

COA / SDS

Nrf2 activator

Key Product Details

Chemical Name:	4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
Purity:	≥99%

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Technical Data
Citations

Biological Activity for Oltipraz

Oltipraz is a Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.

Technical Data for Oltipraz

Formula	C₈H₆N₂S₃
Storage	Store at +4°C
Purity	≥99%
CAS Number	64224-21-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oltipraz

Solubility

Soluble Soluble to 50 mM in DMSO

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References for Oltipraz

References are publications that support the biological activity of the product.

Manandhar et al. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol., 2007;577:17 PMID: 17854798
Maher et al. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology, 2007;46:1597 PMID: 17668877
Merrell et al. Induction of drug metabolism enzymes and transporters by oltipraz in rats. J.Biochem.Mol.Toxicol., 2008;22:128 PMID: 18418891

Oltipraz

Tocris Bioscience, part of Bio-Techne | Catalog # 5294

Key Product Details

Biological Activity for Oltipraz

Technical Data for Oltipraz

Solubility for Oltipraz

Dilution Calculator

Reconstitution Calculator

References for Oltipraz

Product Documents for Oltipraz

COA

Certificate of Analysis

SDS

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