ONO 8130

Name: ONO 8130
Brand: Tocris Bioscience
SKU: 5406
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5406

Citations (4)

COA / SDS

EP1 receptor antagonist

Key Product Details

Description:	EP₁ receptor antagonist
Chemical Name:	4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	500.63

View Full Technical Details for ONO 8130

Technical Data
Citations

Biological Activity for ONO 8130

ONO 8130 is an EP₁ receptor antagonist. Exhibits analgesic effect in a mouse model of cystitis. Orally bioavailable.

Compound Libraries for ONO 8130

ONO 8130 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ONO 8130

M. Wt	500.63
Formula	C₂₅H₂₈N₂O₅S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	459841-96-4
PubChem ID	9827317
InChi Key	IOXMDBQCUCDLAF-UHFFFAOYSA-N
Smiles	CC(C)CN(S(C3=NC(C)=CS3)(=O)=O)C1=C(OCC4=CC=C(C(O)=O)C=C4)C=C(CCC2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ONO 8130

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.06	100
	ethanol	10.01	20

Preparing Stock Solutions for ONO 8130

The following data is based on the product molecular weight 500.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.97 mL
5 mM	0.40 mL	2.00 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for ONO 8130

References are publications that support the biological activity of the product.

Lipina Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 2005 PMID: 15759151
Miki ONO-8130, a selective prostanoid EP₁ receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 2011 PMID: 21396778