Orlistat

Name: Orlistat
Brand: Tocris Bioscience
SKU: 3540

Tocris Bioscience, part of Bio-Techne | Catalog # 3540

Citations (11)

COA / SDS

Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity

Key Product Details

Chemical Name:	N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
Purity:	≥98%
Molecular Weight:	495.73 kDa

View Full Technical Details for Orlistat

Technical Data
Citations

Biological Activity for Orlistat

Orlistat is a hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A₂, liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G₁/S boundary in vitro. Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo. Orlistat inhibits neutral lipid lipase LIPE and dose-dependently reduces α-synuclein-positive cytoplasmic inclusions in α-synuclein-expressing neuroblastoma cell lines.

Technical Data for Orlistat

M. Wt	495.73 kDa
Formula	C₂₉H₅₃NO₅
Storage	Store at +4°C
Purity	≥98%
CAS Number	96829-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Orlistat

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for Orlistat

References are publications that support the biological activity of the product.

Hadvary et al. The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase. J.Biol.Chem., 1991;266:2021 PMID: 1899234
Kridel et al. Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res., 2004;64:2070 PMID: 15026345
Enc et al. Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects. Am.J.Physiol.Gastrointest.Liver Physiol., 2008;296:G482 PMID: 19109408