OSU 6162 hydrochloride

Name: OSU 6162 hydrochloride
Brand: Tocris Bioscience
SKU: 2599

Tocris Bioscience, part of Bio-Techne | Catalog # 2599

Citations (2)

COA / SDS

Dopamine stabilizer

Key Product Details

Description:	Dopamine stabilizer
Alternative Names:	PNU 96391
Chemical Name:	(3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	317.87

View Full Technical Details for OSU 6162 hydrochloride

Technical Data
Citations

Biological Activity for OSU 6162 hydrochloride

OSU 6162 hydrochloride is a dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (K_i values are 447 and 1305 nM for D₂ and D₃ receptors respectively and > 1 μM for other targets). Exhibits high D₂ receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for OSU 6162 hydrochloride

OSU 6162 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for OSU 6162 hydrochloride

M. Wt	317.87
Formula	C₁₅H₂₃NO₂S.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	156907-84-5
PubChem ID	9836644
InChi Key	LEMGVHZVBREXAD-PFEQFJNWSA-N
Smiles	CCCN(C2)CCC[C@@]2([H])C1=CC=CC(S(=O)(C)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OSU 6162 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.79	100
	DMSO	31.79	100

Preparing Stock Solutions for OSU 6162 hydrochloride

The following data is based on the product molecular weight 317.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.73 mL	31.46 mL
5 mM	0.63 mL	3.15 mL	6.29 mL
10 mM	0.31 mL	1.57 mL	3.15 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for OSU 6162 hydrochloride

References are publications that support the biological activity of the product.

Natesan The DA stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potentia J.Pharmacol.Exp.Ther. 2006 PMID: 16648369
Rung The DArgic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog.Neuro-Psychopharm.Biol.Psychiat.
Nichols PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by DA agonists in a rat model for Parkinson's disease. Neuropharmacology 2002 PMID: 12384167