P-3F_AX-Neu5Ac

Name: P-3F AX -Neu5Ac
Brand: Tocris Bioscience
SKU: 5760

Tocris Bioscience, part of Bio-Techne | Catalog # 5760

Citations (6)

COA / SDS

Sialic acid analog; sialyltransferase inhibitor

Key Product Details

Description:	Sialic acid analog; sialyltransferase inhibitor
Chemical Name:	5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
Purity:	≥97% (HPLC)
Molecular Weight:	551.47

View Full Technical Details for P-3F_AX-Neu5Ac

Technical Data
Citations

Biological Activity for P-3F_AX-Neu5Ac

P-3F_AX-Neu5Ac is a cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLe^x expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.

Technical Data for P-3F_AX-Neu5Ac

M. Wt	551.47
Formula	C₂₂H₃₀FNO₁₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	117405-58-0
PubChem ID	72698605
InChi Key	COXHVKPJIOSDPS-RTEYEINBSA-N
Smiles	FC1C(OC(C)=O)C(NC(C)=O)C([C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C(OC)=O)1OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for P-3F_AX-Neu5Ac

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	55.15	100
	ethanol	27.57	50

Preparing Stock Solutions for P-3F_AX-Neu5Ac

The following data is based on the product molecular weight 551.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.07 mL	18.13 mL
5 mM	0.36 mL	1.81 mL	3.63 mL
10 mM	0.18 mL	0.91 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for P-3F_AX-Neu5Ac

References are publications that support the biological activity of the product.

Büll Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 2015 PMID: 25575241
Rillahan Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 2012 PMID: 22683610

P-3F_AX-Neu5Ac

Tocris Bioscience, part of Bio-Techne | Catalog # 5760

Key Product Details

Biological Activity for P-3F_AX-Neu5Ac

Technical Data for P-3F_AX-Neu5Ac

Solubility for P-3F_AX-Neu5Ac

Preparing Stock Solutions for P-3F_AX-Neu5Ac

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for P-3F_AX-Neu5Ac

Product Documents for P-3F_AX-Neu5Ac

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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P-3FAX-Neu5Ac

Tocris Bioscience, part of Bio-Techne | Catalog # 5760

Key Product Details

Biological Activity for P-3FAX-Neu5Ac

Technical Data for P-3FAX-Neu5Ac

Solubility for P-3FAX-Neu5Ac

Preparing Stock Solutions for P-3FAX-Neu5Ac

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for P-3FAX-Neu5Ac

Product Documents for P-3FAX-Neu5Ac

COA

Certificate of Analysis

SDS

P-3F_AX-Neu5Ac

Biological Activity for P-3F_AX-Neu5Ac

Technical Data for P-3F_AX-Neu5Ac

Solubility for P-3F_AX-Neu5Ac

Preparing Stock Solutions for P-3F_AX-Neu5Ac

References for P-3F_AX-Neu5Ac

Product Documents for P-3F_AX-Neu5Ac