p-Chlorophenylalanine

Name: p -Chlorophenylalanine
Brand: Tocris Bioscience
SKU: 0938

Tocris Bioscience, part of Bio-Techne | Catalog # 0938

Citations (6)

COA / SDS

Tryptophan hydroxylase inhibitor

Key Product Details

Description:	Tryptophan hydroxylase inhibitor
Purity:	≥99% (HPLC)
Molecular Weight:	199.64

View Full Technical Details for p-Chlorophenylalanine

Technical Data
Citations

Biological Activity for p-Chlorophenylalanine

p-Chlorophenylalanine is a binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.

Technical Data for p-Chlorophenylalanine

M. Wt	199.64
Formula	C₉H₁₀ClNO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	7424-00-2
PubChem ID	4652
InChi Key	NIGWMJHCCYYCSF-UHFFFAOYSA-N
Smiles	NC(C(O)=O)CC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for p-Chlorophenylalanine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		10

Preparing Stock Solutions for p-Chlorophenylalanine

The following data is based on the product molecular weight 199.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	50.09 mL	250.45 mL	500.90 mL
0.5 mM	10.02 mL	50.09 mL	100.18 mL
1 mM	5.01 mL	25.05 mL	50.09 mL
5 mM	1.00 mL	5.01 mL	10.02 mL

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Reconstitution Calculator

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References for p-Chlorophenylalanine

References are publications that support the biological activity of the product.

Koyuncuoglu The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 1975 PMID: 129787
Datla and Curzon Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 1996 PMID: 8783206