PA 452

Name: PA 452
Brand: Tocris Bioscience
SKU: 5086

Tocris Bioscience, part of Bio-Techne | Catalog # 5086

Citations (7)

COA / SDS

RXR antagonist

Discontinued Product

5086 has been discontinued. View all Retinoid X Receptor Antagonists products.

Key Product Details

Description:	RXR antagonist
Chemical Name:	2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	439.59

View Full Technical Details for PA 452

Technical Data
Citations

Biological Activity for PA 452

PA 452 is an RXR antagonist (pA₂ = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.

Technical Data for PA 452

M. Wt	439.59
Formula	C₂₆H₃₇N₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	457657-34-0
PubChem ID	9803242
InChi Key	JJUUTJCZMGZJDZ-UHFFFAOYSA-N
Smiles	CC1(C)C2=C(C=C(N(C3=NC=C(C(O)=O)C=N3)C)C(OCCCCCC)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PA 452

References are publications that support the biological activity of the product.

Takahashi Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. J.Med.Chem. 2002 PMID: 12139443
Nakayama Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB. J.Med.Chem.Lett 2011 PMID: 24900278
Yasmin Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch. J.Mol.Biol. 2010 PMID: 20188110

PA 452

Tocris Bioscience, part of Bio-Techne | Catalog # 5086

Key Product Details

Biological Activity for PA 452

Technical Data for PA 452

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PA 452

Product Documents for PA 452

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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