PAC 1

Name: PAC 1
Brand: Tocris Bioscience
SKU: 2581

Tocris Bioscience, part of Bio-Techne | Catalog # 2581

Citations (10)

COA / SDS

Activator of procaspase-3; pro-apoptotic

Key Product Details

Chemical Name:	4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for PAC 1

PAC 1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC₅₀ = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC₅₀ = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC₅₀ values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).

Technical Data for PAC 1

Formula	C₂₃H₂₈N₄O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	315183-21-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PAC 1

Solubility

Soluble Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO

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References for PAC 1

References are publications that support the biological activity of the product.

Putt et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat.Chem.Biol., 2006;2:543 PMID: 16936720
Peterson et al. Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. J.Med.Chem., 2009;52:5721 PMID: 19708658

PAC 1

Tocris Bioscience, part of Bio-Techne | Catalog # 2581

Key Product Details

Biological Activity for PAC 1

Technical Data for PAC 1

Solubility for PAC 1

Dilution Calculator

Reconstitution Calculator

References for PAC 1

Product Documents for PAC 1

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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