PACAP 1-27

Name: PACAP 1-27
Brand: Tocris Bioscience
SKU: 1183

Tocris Bioscience, part of Bio-Techne | Catalog # 1183

Citations (4)

COA / SDS

Potent stimulator of adenylyl cyclase

Key Product Details

Description:	Potent stimulator of adenylyl cyclase
Alternative Names:	Pituitary Adenylate Cyclase-Activating Polypeptide 1-27
Purity:	≥95% (HPLC)
Molecular Weight:	3147.6

View Full Technical Details for PACAP 1-27

Technical Data
Citations

Biological Activity for PACAP 1-27

PACAP 1-27 is an endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP). Potently stimulates adenylyl cyclase.

Technical Data for PACAP 1-27

M. Wt	3147.6
Formula	C₁₄₂H₂₂₄N₄₀O₃₉S
Single Letter Sequence	HSDGIFTDSYSRYRKQMAVKKYLAAVL (Modifications: Leu-27 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	127317-03-7
PubChem ID	16137193
InChi Key	RZGBUJXSKLDAFE-QYHUGZLJSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PACAP 1-27

Solubility

Soluble to 1mg/ml in water

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References for PACAP 1-27

References are publications that support the biological activity of the product.

Michel XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 1998 PMID: 9549761
Rawlings Pituitary adenylate cyclase-activating polypeptide increase [Ca²⁺]i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism. J.Biol.Chem. 1994 PMID: 7907085
Hirose Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anaesthetized dogs. J.Pharmacol.Exp.Ther. 1997 PMID: 9353360