PACMA 31

Name: PACMA 31
Brand: Tocris Bioscience
SKU: 5116

Tocris Bioscience, part of Bio-Techne | Catalog # 5116

Citations (3)

COA / SDS

Irreversible protein disulfide isomerase (PDI) inhibitor

Key Product Details

Description:	Irreversible protein disulfide isomerase (PDI) inhibitor
Chemical Name:	N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	430.47

View Full Technical Details for PACMA 31

Technical Data
Citations

Biological Activity for PACMA 31

PACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.

Compound Libraries for PACMA 31

PACMA 31 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PACMA 31

M. Wt	430.47
Formula	C₂₁H₂₂N₂O₆S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1401089-31-3
PubChem ID	66555902
InChi Key	AHOOZADJPNUFOQ-UHFFFAOYSA-N
Smiles	O=C(C#C)N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C1=CC=C(OC)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PACMA 31

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.05	100

Preparing Stock Solutions for PACMA 31

The following data is based on the product molecular weight 430.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.62 mL	23.23 mL
5 mM	0.46 mL	2.32 mL	4.65 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for PACMA 31

References are publications that support the biological activity of the product.

Xu Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 22988091
Ge Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 2013 PMID: 24070012