Palmitoylethanolamide

Name: Palmitoylethanolamide
Brand: Tocris Bioscience
SKU: 0879

Tocris Bioscience, part of Bio-Techne | Catalog # 0879

Citations (13)

COA / SDS

Selective GPR55 agonist. FAAH and PAA substrate

Key Product Details

Description:	Selective GPR55 agonist. FAAH and PAA substrate
Alternative Names:	PEA
Chemical Name:	N-(2-Hydroxyethyl)hexadecanamide
Molecular Weight:	299.5

View Full Technical Details for Palmitoylethanolamide

Technical Data
Citations

Biological Activity for Palmitoylethanolamide

Palmitoylethanolamide is an endogenous lipid that acts as a selective GPR55 agonist (EC₅₀ values are 4, 19 800 and > 30 000 nM at GPR55, CB₂ and CB₁ receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC₅₀ = 3 μM) producing robust anti-inflammatory actions.

Technical Data for Palmitoylethanolamide

M. Wt	299.5
Formula	C₁₈H₃₇NO₂
Storage	Store at RT
CAS Number	544-31-0
PubChem ID	4671
InChi Key	HXYVTAGFYLMHSO-UHFFFAOYSA-N
Smiles	O=C(CCCCCCCCCCCCCCC)NCCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Palmitoylethanolamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	5.99	20
	ethanol	7.49	25

Preparing Stock Solutions for Palmitoylethanolamide

The following data is based on the product molecular weight 299.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	13.36 mL	66.78 mL	133.56 mL
1.25 mM	2.67 mL	13.36 mL	26.71 mL
2.5 mM	1.34 mL	6.68 mL	13.36 mL
12.5 mM	0.27 mL	1.34 mL	2.67 mL

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References for Palmitoylethanolamide

References are publications that support the biological activity of the product.

Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
Re Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet.J. 2005 PMID: 16324856
Lambert The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr.Med.Chem. 2002 PMID: 11945130
Lo Verme The search for the palmitoylethanolamide receptor. Life Sci. 2005 PMID: 15963531
Lambert Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia 2001 PMID: 11442148