PD 102807

Name: PD 102807
Brand: Tocris Bioscience
SKU: 1671
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1671

(1)

Citations (24)

COA / SDS

Selective M4 antagonist

Key Product Details

Description:	Selective M₄ antagonist
Chemical Name:	3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	392.45

View Full Technical Details for PD 102807

Technical Data
Citations / Reviews (1)

Biological Activity for PD 102807

PD 102807 is a selective M₄ muscarinic receptor antagonist. IC₅₀ values are 91, 6559, 3441, 950 and 7412 nM for human M₄, M₁, M₂, M₃, and M₅ receptors respectively. Promotes self-renewal of erythroid progenitors.

Compound Libraries for PD 102807

PD 102807 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PD 102807

M. Wt	392.45
Formula	C₂₃H₂₄N₂O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	23062-91-1
PubChem ID	4995951
InChi Key	VDDUJINYXKGZLV-UHFFFAOYSA-N
Smiles	CCOC(=O)C1=C(C)NC2=CC=C3OC4N(CCC5=CC(OC)=CC=C45)CC3=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 102807

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.24	100

Preparing Stock Solutions for PD 102807

The following data is based on the product molecular weight 392.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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Reconstitution Calculator

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References for PD 102807

References are publications that support the biological activity of the product.

Trivedi Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors. Sci.Transl.Med. 2019 PMID: 31554738
Bohme Synthesis and pharmacology of benzoxazines as highly selective antagonists at M₄ muscarinic receptors. J.Med.Chem. 2002 PMID: 12086495
Kitaichi A novel muscarinic M₄ receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M₂ receptor sub-type. Eur.J.Pharmacol. 1999 PMID: 10556681
Augelli-Szafran Identification and characterization of m4 selective muscarinic antagonists. Bioorg.Med.Chem.Lett. 1998 PMID: 9873472