PD 146176

Name: PD 146176
Brand: Tocris Bioscience
SKU: 2850

Tocris Bioscience, part of Bio-Techne | Catalog # 2850

Citations (16)

COA / SDS

Selective 15-lipoxygenase inhibitor

Key Product Details

Description:	Selective 15-lipoxygenase inhibitor
Chemical Name:	6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
Purity:	≥98% (HPLC)
Molecular Weight:	237.32

View Full Technical Details for PD 146176

Technical Data
Citations

Biological Activity for PD 146176

PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K_i = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC₅₀ = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.

Compound Libraries for PD 146176

PD 146176 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PD 146176

M. Wt	237.32
Formula	C₁₅H₁₁NS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	4079-26-9
PubChem ID	297589
InChi Key	ZGOOPZVQMLHPFM-UHFFFAOYSA-N
Smiles	C12=CC=CC=C1C3=C(C(C=CC=C4)=C4SC3)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 146176

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.73	100
	ethanol	11.87	50

Preparing Stock Solutions for PD 146176

The following data is based on the product molecular weight 237.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.21 mL	21.07 mL	42.14 mL
5 mM	0.84 mL	4.21 mL	8.43 mL
10 mM	0.42 mL	2.11 mL	4.21 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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References for PD 146176

References are publications that support the biological activity of the product.

Bocan A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis 1998 PMID: 9543090
Sordillo Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat. 2005 PMID: 15967159
Sendobry Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br.J.Pharmacol. 1997 PMID: 9105693