PD 161570

Name: PD 161570
Brand: Tocris Bioscience
SKU: 3724

Tocris Bioscience, part of Bio-Techne | Catalog # 3724

Citations (10)

COA / SDS

Selective FGFR inhibitor

Key Product Details

Description:	Selective FGFR inhibitor
Chemical Name:	N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Purity:	≥97% (HPLC)
Molecular Weight:	532.51

View Full Technical Details for PD 161570

Technical Data
Citations

Biological Activity for PD 161570

PD 161570 is a selective FGFR inhibitor (IC₅₀ values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC₅₀ = 622 nM) and growth of A121 cells in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PD 161570

PD 161570 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for PD 161570

M. Wt	532.51
Formula	C₂₆H₃₅Cl₂N₇O
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	192705-80-9
PubChem ID	5328135
InChi Key	MKVMEJKNLUWFSQ-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(Cl)=C1C3=CC2=CN=C(NCCCCN(CC)CC)N=C2N=C3NC(NC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 161570

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	53.25	100
	ethanol	53.25	100

Preparing Stock Solutions for PD 161570

The following data is based on the product molecular weight 532.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.39 mL	18.78 mL
5 mM	0.38 mL	1.88 mL	3.76 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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Reconstitution Calculator

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References for PD 161570

References are publications that support the biological activity of the product.

Batley Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor. Life Sci. 1998 PMID: 9488112
Stevens Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol.Endocrinology 2003 PMID: 12805413
Hamby Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J.Med.Chem. 1997 PMID: 9240345