PD 184352

Name: PD 184352
Brand: Tocris Bioscience
SKU: 4237
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4237

(1)

Citations (19)

COA / SDS

Selective MEK inhibitor

Key Product Details

Description:	Selective MEK inhibitor
Alternative Names:	CI-1040
Chemical Name:	2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	478.66

View Full Technical Details for PD 184352

Technical Data
Citations / Reviews (1)

Biological Activity for PD 184352

PD 184352 is a selective MEK inhibitor (K_i = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PD 184352

M. Wt	478.66
Formula	C₁₇H₁₄ClF₂IN₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	212631-79-3
PubChem ID	6918454
InChi Key	GFMMXOIFOQCCGU-UHFFFAOYSA-N
Smiles	FC1=C(NC2=CC=C(I)C=C2Cl)C(C(NOCC3CC3)=O)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 184352

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.87	100
	ethanol	11.97	25

Preparing Stock Solutions for PD 184352

The following data is based on the product molecular weight 478.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.45 mL	20.89 mL
5 mM	0.42 mL	2.09 mL	4.18 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for PD 184352

References are publications that support the biological activity of the product.

McDaid Enhancement of the therapeutic efficacy of Tax. by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants. Cancer Res. 2005 PMID: 15805287
Solit BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006 PMID: 16273091
Allen CI-1040 (PD184252), a targeted signal transduction inhibitor of MEK (MAPKK). Semin.Oncol. 2003 PMID: 14613031