PD 198306

Name: PD 198306
Brand: Tocris Bioscience
SKU: 2605
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2605

(1)

Citations (10)

COA / SDS

Selective inhibitor of MEK1/2

Key Product Details

Description:	Selective inhibitor of MEK1/2
Chemical Name:	N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	476.23

View Full Technical Details for PD 198306

Technical Data
Citations / Reviews (1)

Biological Activity for PD 198306

PD 198306 is a potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC₅₀ values are > 1, > 4, > 4 and > 10 μM for ERK, c-Src, cdks and PI 3-kinase γ respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration.

Technical Data for PD 198306

M. Wt	476.23
Formula	C₁₈H₁₆F₃IN₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	212631-61-3
PubChem ID	9956637
InChi Key	UHAXDAKQGVISBZ-UHFFFAOYSA-N
Smiles	CC1=C(NC2=C(C=C(F)C(F)=C2F)C(=O)NOCC2CC2)C=CC(I)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 198306

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.62	100
	ethanol	47.62	100

Preparing Stock Solutions for PD 198306

The following data is based on the product molecular weight 476.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.10 mL	10.50 mL	21.00 mL
5 mM	0.42 mL	2.10 mL	4.20 mL
10 mM	0.21 mL	1.05 mL	2.10 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for PD 198306

References are publications that support the biological activity of the product.

Pelletier In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. Arthrit.Rheumat.
Ciruela Identification of MEK1 as a novel target for the treatment of neuropathic pain. Br.J.Pharmacol. 2003 PMID: 12642375