PDD 00017238

Name: PDD 00017238
Brand: Tocris Bioscience
SKU: 7007

Tocris Bioscience, part of Bio-Techne | Catalog # 7007

Citations (7)

COA / SDS

High affinity and potent PARG inhibitor

Key Product Details

Description:	High affinity and potent PARG inhibitor
Chemical Name:	1-[(2,4-Dimethyl-5-thiazolyl)methyl]-2,3-dihydro-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)-1H-benzimidazole-5-sulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	476.59

View Full Technical Details for PDD 00017238

Technical Data
Citations

Biological Activity for PDD 00017238

PDD 00017238 is a high affinity and potent PARG inhibitor (K_d = 3.09 nM; IC₅₀ = 40 nM).

Negative control PDD 00031705 (Cat. No. 7009) also available.

Licensing Information

Sold under license from Cancer Research Technology Ltd (Ximbio).

Technical Data for PDD 00017238

M. Wt	476.59
Formula	C₁₉H₂₀N₆O₃S₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1952247-05-0
PubChem ID	121415983
InChi Key	FLUZEVGWXJVSPX-UHFFFAOYSA-N
Smiles	CC1=NC(C)=C(S1)CN2C(N(C3=CC(S(=O)(NC4(CC4)C)=O)=CC=C23)C5=NC=NS5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PDD 00017238

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	0.95	2

Preparing Stock Solutions for PDD 00017238

The following data is based on the product molecular weight 476.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	104.91 mL	524.56 mL	1,049.12 mL
0.1 mM	20.98 mL	104.91 mL	209.82 mL
0.2 mM	10.49 mL	52.46 mL	104.91 mL
1 mM	2.10 mL	10.49 mL	20.98 mL

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References for PDD 00017238

References are publications that support the biological activity of the product.

James First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib. ACS Chem.Biol. 2016 PMID: 27689388