PDD 00017272

Name: PDD 00017272
Brand: Tocris Bioscience
SKU: 7006

Tocris Bioscience, part of Bio-Techne | Catalog # 7006

Citations (3)

COA / SDS

Potent PARG inhibitor

Key Product Details

Description:	Potent PARG inhibitor
Chemical Name:	1-[(2,4-Dimethyl-5-thiazolyl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	531.66

View Full Technical Details for PDD 00017272

Technical Data
Citations

Biological Activity for PDD 00017272

PDD 00017272 is a potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC₅₀ values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).

Licensing Information

Sold under license from Cancer Research Technology Ltd (Ximbio).

Technical Data for PDD 00017272

M. Wt	531.66
Formula	C₂₃H₂₅N₅O₄S₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1945950-20-8
PubChem ID	134169694
InChi Key	QOEXRJYTAZZRPL-UHFFFAOYSA-N
Smiles	CC1=NC=C(S1)CN2C(N(C3=CC=C(S(=O)(NC4(CC4)C)=O)C=C3C2=O)CC5=C(N=C(S5)C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PDD 00017272

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.63	20 with gentle warming

Preparing Stock Solutions for PDD 00017272

The following data is based on the product molecular weight 531.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.40 mL	47.02 mL	94.05 mL
1 mM	1.88 mL	9.40 mL	18.81 mL
2 mM	0.94 mL	4.70 mL	9.40 mL
10 mM	0.19 mL	0.94 mL	1.88 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for PDD 00017272

References are publications that support the biological activity of the product.

Waszkowycz Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 2018 PMID: 30403352