PDD 00017272

Name: PDD 00017272
Brand: Tocris Bioscience
SKU: 7006

Tocris Bioscience, part of Bio-Techne | Catalog # 7006

Citations (3)

COA / SDS

Potent PARG inhibitor

Key Product Details

Chemical Name:	1-[(2,4-Dimethyl-5-thiazolyl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
Purity:	≥98%

View Full Technical Details for PDD 00017272

Technical Data
Citations

Biological Activity for PDD 00017272

PDD 00017272 is a potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC₅₀ values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).

Technical Data for PDD 00017272

Formula	C₂₃H₂₅N₅O₄S₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	1945950-20-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PDD 00017272

Solubility

Soluble Soluble to 20 mM in DMSO with gentle warming

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References for PDD 00017272

References are publications that support the biological activity of the product.

Waszkowycz et al. Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem., 2018;61:10767 PMID: 30403352

PDD 00017272

Tocris Bioscience, part of Bio-Techne | Catalog # 7006

Key Product Details

Biological Activity for PDD 00017272

Technical Data for PDD 00017272

Solubility for PDD 00017272

Dilution Calculator

Reconstitution Calculator

References for PDD 00017272

Product Documents for PDD 00017272

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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