PDEδ ATTEC 12C

Name: PDEδ ATTEC 12C
Brand: Tocris Bioscience
SKU: 8824

Tocris Bioscience, part of Bio-Techne | Catalog # 8824

COA / SDS

PDEδ autophagy-tethering compound (ATTEC) Degrader

Key Product Details

Description:	PDEδ autophagy-tethering compound (ATTEC) Degrader
Chemical Name:	N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide
Purity:	≥98% (HPLC)
Molecular Weight:	999.54

View Full Technical Details for PDEδ ATTEC 12C

Technical Data
Citations

Biological Activity for PDEδ ATTEC 12C

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC₅₀ = 1.7 μM; D_max = 85%; K_d = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC₅₀ values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.

Technical Data for PDEδ ATTEC 12C

M. Wt	999.54
Formula	C₄₁H₄₂Br₂IN₇O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	BYPQUTISFKWFMK-DXJNIWACSA-N
Smiles	BrC1=CC(/C=C2C(C=C(I)C=C3)=C3NC/2=O)=CC(Br)=C1OCC(NCCCCCCNC(CCCN4C(C5=NN(C6=CC=C(C)C=C6)C(C)=C5C(C)=N4)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PDEδ ATTEC 12C

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	19.99	20

Preparing Stock Solutions for PDEδ ATTEC 12C

The following data is based on the product molecular weight 999.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	5.00 mL	25.01 mL	50.02 mL
1 mM	1.00 mL	5.00 mL	10.00 mL
2 mM	0.50 mL	2.50 mL	5.00 mL
10 mM	0.10 mL	0.50 mL	1.00 mL

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References for PDEδ ATTEC 12C

References are publications that support the biological activity of the product.

Bao Discovery of novel PDEδ autophagic degraders: a case study of autophagy-tethering compound (ATTEC). ACS Med.Chem.Lett. 2024 PMID: 38229750