pep2-EVKI

Name: pep2-EVKI
Brand: Tocris Bioscience
SKU: 1599

Tocris Bioscience, part of Bio-Techne | Catalog # 1599

Citations (2)

COA / SDS

Peptide inhibitor of GluA2 subunit binding to PICK1

Discontinued Product

1599 has been discontinued. View all AMPA Receptor Inhibitors products.

Key Product Details

Description:	Peptide inhibitor of GluA2 subunit binding to PICK1
Molecular Weight:	1326.51

View Full Technical Details for pep2-EVKI

Technical Data
Citations

Biological Activity for pep2-EVKI

pep2-EVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).

Technical Data for pep2-EVKI

M. Wt	1326.51
Formula	C₆₂H₉₅N₁₃O₁₉
Single Letter Sequence	YNVYGIEEVKI
Storage	Desiccate at -20°C
CAS Number	1315378-67-6
PubChem ID	90479809
InChi Key	KGQYILLVACJAQP-XMCCVONBSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for pep2-EVKI

References are publications that support the biological activity of the product.

Li AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 1999 PMID: 10526335
Daw PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 2000 PMID: 11163273
Hanley Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Neuron 2002 PMID: 11931741
Collingridge and Isaac Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 2003 PMID: 12941441

pep2-EVKI

Tocris Bioscience, part of Bio-Techne | Catalog # 1599

Key Product Details

Biological Activity for pep2-EVKI

Technical Data for pep2-EVKI

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for pep2-EVKI

Product Documents for pep2-EVKI

COA

Certificate of Analysis

SDS

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